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Fig. 6. Monocular retinal blockade of ERK activation. (A,B,D,E) Representative
images of both sides of the dLGN of rats that received monocular injections of
beads-U0126 (A,B; n=7) or vehicle (D,E; n=7). Projections
from the treated eye are labeled with CTB-Alexa Fluor 488 (green) and those
from untreated eye with CTB-Alexa Fluor 594 (red). Note that in the
U0126-treated animals both contralateral (A) and ipsilateral (B) fibers from
the treated eye (green) occupy smaller territories then the corresponding
projections from the untreated eye (red, A,B). Conversely, in control rats
(D,E), fibers from both eyes occupy similar areas in the dLGN. (C,F) Cresyl
violet staining of cells in the GCL. Living cell density in the retinas of
rats monocularly injected with U0126 (C; 69.3±6.1 cells per field,
n=5) is not statistically different (Student's t-test,
P>0.05) from that of vehicle-treated retinas (F; 66.1±2.5
cells per field, n=4). Scale bars: 200 µm for A,B,D,E; 20 µm
for C,F.
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