QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

Help viewing high resolution images Return to article

Fig. 4. Inhibition of Fgf activity prevents formation of vegetal prospective neural tissue. Lateral views with dorsal right of gastrula stage embryos (80-90% epiboly). Wild-type embryos (A,E,G,I,K) and embryos treated with SU5402, a Fgf receptor inhibitor (B,C,D, with 60 µM SU5402; F,H,J,L, with 90 µM) labelled to show sox3 (A-D), sox31 (E,F) and zix2.2 (G,H) expression, the anterior neural marker gene, otx2 (I,J), and the non neural marker gene, p63 (K,L). The arrowheads in AD indicate the variable decrease in vegetal sox3 expression and the asterisks show that the animal (anterior) domain of sox3 expression is largely unaffected (although repositioned closer to the vegetal side of the embryo).

Return to article