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Fig. 7. Combinatorial activity of Bmp and Fgf signals promotes expression of
different regional markers of the gastrula ectoderm. Lateral views of late
gastrula stage embryos with dorsal towards the right. Genes analysed are
indicated to the left of the rows: otx2, prospective head neural
ectoderm; hoxb1b, prospective trunk neural ectoderm; eve1,
prospective tail neural ectoderm and mesoderm; p63, prospective
epidermis. Bmp activity was modulated by expression of exogenous
chordin or bmp2b; Fgf activity was modulated by expression
of a dominant-negative Fgf receptor (XFD) or fgf3. The presumed state
of activation of the two pathways is indicated in red/green above each column.
Note that overexpression of fgf3 (E) induces chordin (see
Fig. 2Q) and therefore
suppresses Bmp activity (Koshida et al.,
2002).
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