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Fig. 7. Aberrant migration and defective differentiation of the dorsal horn neurons
in wild-type and Rnx-/- and Drg11-/-
mutant embryos. (A) Neurons labeled with BrdU at E11.5 are not detected in the
outer layer of laminae I-II (bracket) in wild-type embryo at E14.5 (inset).
(B) Neurons labeled with BrdU at E11.5 are detected in the outer layer of
laminae I-II in Rnx-/- embryo (inset, bracket). (C)
Quantitative comparison of the number of BrdU+ neurons in the
medial one-third (Med 1/3) and lateral two-thirds (Lat 2/3) regions between
wild-type and Rnx-/- embryos
(*P<0.001). (D,E) Comparison of the distribution
pattern of neurons labeled with BrdU at E11.5 in the dorsal horn of E14.5
wild-type (D) and Drg11 mutants (E). (F) Quantitative analysis of the
numbers of BrdU-labeled neurons in the medial and lateral regions of wild-type
and Drg11 mutant embryos (*P<0.001). (G,H)
MAP2 expression in the dorsal horn of wild-type (G, bracket) and Rnx
mutant embryos (H, bracket). MAP2 expression of the dorsal horn in wild-type
(I, bracket) and Drg11-/- mutant embryos (J, bracket).
Scale bars: in B and C, 100 µm for A and D, respectively; 50 µm in
insets in B and E; 100 µm in G-J.
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