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Fig. 8. Selective block of the ingrowth of cutaneous afferents in the dorsal spinal
cord of Lmx1b-/- mutant embryos at E14.5. (A,B)
Immunocytochemical detection of TrkA in the dorsal horn of wild-type (A) and
Lmx1b-/- mutant (B) embryos. Arrows indicate the
superficial laminae region. Brackets outline laminae I-II region. (C,D)
Peripherin detection in the dorsal horn of wild-type (C) and Lmx1b
mutant embryos (D) appears unchanged. Arrows indicate peripherin-labeled
presumptive proprioceptive afferents. (E,F) DiI labeling of primary afferents
in the dorsal horn of wild-type (E) and Lmx1b mutant embryos (F).
Arrowheads indicate presumptive mechanoreceptor afferents and arrows indicate
presumptive muscle proprioceptive afferents. Asterisks and brackets outline
laminae I-II region. (G,H) Sema3c expression in wild-type (G) and
Lmx1b mutant embryos (H). (I,J) Nrp1 expression in wild-type
(I) and Lmx1b mutant embryos (J). (K,L) Plexin A2 expression in
wild-type (K) and Lmx1b mutant embryos (L). (M,N) Slit1
expression in wild-type (M) and Lmx1b mutant embryos (N). (O,P)
Robo2 expression in wild-type (O) and Lmx1b mutant embryos
(P). (Q,R) Netrin 1 expression in wild-type (Q) and Lmx1b
mutant embryos (R). Arrows in G-S indicate laminae I-II. Arrowheads in Q and R
indicate the lateral region of laminae I-II. Scale bars: 200 µm in A, B;
100 µm in C-R.
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