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Fig. 5. The distributions of Ephb2 and ephrin B2 proteins in the developing retina and its axons are not dramatically altered in the Foxg1^-/- mutant. Ephrin B2 protein forms a dorsolateral^[High] to ventrolateral^[Low] gradient in the developing retina at E13.5 in (A) the wild-type and (C) the mutant. This gradient remains at E16.5 in both (B) wild-type and (D) mutant. Ephb2 protein forms a complementary ventrolateral^[High] to dorsolateral^[Low] gradient in the developing retina at E13.5 in both (E) wild-type and (G) mutant retina. At E16.5, these gradients are shallower than at E13.5 in both (F) wild type and (H) mutant. The optic nerve (on) stains strongly for Ephb2 protein consistent with Ephb2 expression by navigating RGC axons. (I,J) In the wild type, Ephb2 is present in the optic nerve as it leaves the retina (r) and approaches the optic chiasm (oc) to emerge into the optic tract (ot) (boxed area in I). (K,L) In the mutant, Ephb2 is expressed in the elongated retina (er), at the optic chiasm and in the mutant optic tract as it emerges from the chiasm (boxed area in K). (A-H) Coronal sections (dorsal is towards the top); (I-L) horizontal sections (posterior is towards the top). Scale bars: 100 µm in A-H; 200 µm I-L.

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