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Fig. 6. Morphological alterations of the brain in
Sox2ß-geo/
ENH mutants. (A) Dorsal view of
wild-type (top) and mutant (bottom) brains. The shrinkage of the
medial-posterior cortex is particularly visible in this mutant. (B-F) Coronal
sections through adult forebrain of a normal (top) and a mutant (bottom)
mouse. Sections were matched between normal and mutant brains on the basis of
the correspondence of characteristic anatomical landmarks (hippocampus,
thalamic nuclei and fibre tracts). Left, anteriormost; right, posteriormost.
Asterisk indicates thalamic nuclei (see
Fig. 2F). Black circle, dorsal
striatum; white circle, septum; arrowhead and arrow in E, corpus callosum.
Black arrow in F-H marks the diminished extension of the cortex. (G-I)
Coronal sections at E14.5 (G,H) and P0 (I) of normal (top) and mutant (bottom)
brains. Note, in G and H, the ventricles of the mutant are normal, and the
thalamus and striatum sizes are essentially normal, in contrast to the reduced
cortex (particularly visible in H).
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