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First published online August 2, 2004

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News Dispatch: Hedgehog trafficking update

Hedgehog (Hh) proteins – membrane-associated signals involved in many developmental processes – can elicit signalling responses at considerable distances away from the cells that secrete them, and the transmembrane protein Dispatched (Disp) plays a key role in this journey. Tian and colleagues (p. 4021) now investigate the function of mammalian Disp1 during embryogenesis, and shed light on the mode of Disp action. Using mice with a hypomorphic Disp1 allele, the researchers found that Disp1 has a dose-dependent effect on the severity of Hh-dependent phenotypes, such as those affecting facial morphology, and ventral forebrain, telencephalon and neural tube patterning. Furthermore, as Disp1 levels are reduced, ventral cell identities in the neural tube are progressively lost, while increasing Hh levels restores ventral cell types. The researchers conclude that Disp1 regulates the levels of Hh protein available in the target tissue, and they discuss several possible mechanisms of Disp action during Hh signaling.

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Related articles in Development:

Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse

Hua Tian, Toyoaki Tenzen, and Andrew P. McMahon
Development 2004 131: 4021-4033. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?