spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online August 2, 2004

Development 131, 1606e (2004)
© The Company of Biologists Limited
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

In this issue

Tbx5 gets the heart beating

Holt-Oram syndrome (HOS), which results from mutations in the gene TBX5, causes cardiac rhythm abnormalities. Moskowitz et al. (p. 4107) now report several distinct roles for Tbx5 in the patterning and maturation of the mouse heart conduction system – the myocardial cells that coordinate the contraction of the multichambered heart. They show that Tbx5 is expressed throughout the central conduction system from early heart development. Mice with Tbx5 haploinsufficiency have postnatal morphological and functional defects in the proximal atrioventricular conduction system and earlier patterning abnormalities in the distal atrioventricular conduction system. In particular, the complete absence of a part of the conduction system – the right bundle branch – results in a conduction delay. Tbx5 is the first gene implicated in both the patterning and maturation of the central conduction system, and Moskowitz et al. consider how this may shed light on the pathology of HOS.


Related articles in Development:

The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system
Ivan P. G. Moskowitz, Anne Pizard, Vickas V. Patel, Benoit G. Bruneau, Jae B. Kim, Sabina Kupershmidt, Dan Roden, Charles I. Berul, Christine E. Seidman, and Jonathan G. Seidman
Development 2004 131: 4107-4116. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content