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Fig. 2. Transcription factors controlling eye development, shown in a mouse embryo at the optic vesicle stage. Rx (red) is expressed in an anterior region of the neural tube and is necessary for optic vesicle evagination, proliferation of cells in the optic vesicle and retinal differentiation. Pax6 (green) is important in both the optic vesicle and the lens placode, where its expression might be regulated by Meis and Sox transcription factors. Otx proteins (blue) promote the development of the retinal pigment epithelium (RPE).





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