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Fig. 3. Morphology of the PNS in control and mutant embryos on E10.5 and E11.5.
(A,B) Detection of ß-galactosidase activity after targeted deletion of
the floxed ß1-integrin locus in whole-mount control (A) and mutant (B)
embryos, in the DRG and spinal nerves in the trunk on E10.5. (C,D) Hu-D
immunolocalisation in transverse sections of control (C) and mutant (D)
thoracic DRG of E10.5 embryos. (E-H) Whole-mount NF-160 immunostaining labels
cranial sensory nerves in control (E,G) and mutant (F,H) embryos on E10.5
(E,F) and E11.5 (G,H), respectively. E11.5 embryos were treated with BABB. The
position of nerves is indicated in E. The black arrowhead in F illustrates the
fusion of nerves IX and X in the mutant on E10.5. The white arrowhead
indicates a decrease in the number of nerve X roots at the same stage. On
E11.5, structures are similar in the control (G) and mutant (H) embryos,
except for certain changes to the fasciculation of nerve X roots in the
mutant, which exhibits the strongest alteration (white arrowhead in H).
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