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Fig. 2. Fgf8 can induce ectopic expression of Scx in the sclerotome in the absence of the myotome. (A-D) Results of overexpression of Fgf8 in the psm with RCAS-FGF8, followed by surgical removal of dermomyotomes. (A,C) Whole-mount in situ hybridization for Scx following manipulation. Region of dermomyotome removal indicated by red bracket. (B,D) Double whole-mount in situ hybridization for Fgf8 on embryos shown in A,C. Antibody staining for phosphorylated MAPK/ERK (E,F) and myosin heavy chain (MF20) (F) on frontal sections of HH stage 20 embryos. (E) Phosphorylated MAPK/ERK (red) is seen in dorsal sclerotome, myotome and dermomyotome. Blue arrow indicates expression in the sclerotome, purple arrow in the dermomyotome, yellow arrow in the dorsal root ganglia. (F) Overlay of phosphorylated MAPK/ERK (red) and MF20 (green).





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