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Fig. 1. daf-15 encodes the C. elegans raptor. (A) Physical map of the daf-15 region of chromosome IV (corresponding 0.6 map units). (B) A schematic structure of DAF-15 raptor. The predicted RNC domain, HEAT (Huntingtin, elongation factor 3, the regulatory A subunit of PP2A and Tor1p) repeats and WD40 repeats are indicated. Cosmid C10C5 partially rescues a daf-15 mutant, but lacks the last three exons of daf-15 encoding the last four WD40 repeats. Sequence alterations in m81 and m634 are shown. (C) Alignment of the three blocks of the DAF-15 RNC domain with its orthologs. Identical amino acids are in black boxes. The star in block 1 indicates the G194S change in m81. W440 (black dot) is changed to a TGA stop in m634. The numbers beside the sequences indicate the position of the beginning and ending amino acids in the corresponding protein. The GenBank Accession Number of the daf-15 cDNA sequence is AY396716.





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