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Fig. 6. kette and sra-1 function during bristle development. (A-C) Top row, dorsal view of Drosophila heads; bottom row, higher magnification showing the morphology of macrochaetes. (A) Hypomorphic kette mutant flies (ketteJ1-70/kette{Delta}2-6) are characterized by bent bristles (arrow). (B) Following expression of sra-1 dsRNA in the scabrous pattern, similar bent bristles are formed (arrow). Some bristles are missing (star). This phenotypic trait increases following expression of higher levels of Sra-1 RNAi. (C) After expression of a membrane-tethered Sra-1 protein variant lacking the Kette interaction domain (Sra-1{Delta}CMyr), frequent loss of bristles as well as bent bristles is observed.





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