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Fig. 3. Dorsoventral patterning of telencephalon is affected in Disp1 mutants. Coronal sections of E12.5 embryo of wild type, Disp1{Delta}2/{Delta}2, Disp1{Delta}2/C829F, and Disp1{Delta}2/C829F, Shh+/– were assayed for expression of region-specific homeobox gene Nkx2.1 (A-D), Mash1 (E-H), Dlx2 (I-L) and Ngn2 (M-P). Progressive attenuation of Shh-signaling strength through genetic manipulation of Disp1 and Shh genes leads to gradual restriction of Pan-ventral gene markers, including Nkx2.1, Mash1 and Dlx2, to the midline; and corresponding expansion of Pan-dorsal gene Ngn2.





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