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Fig. 5. Ventral neural precursor patterning defects in Disp1 hypomorphic mutants. Motoneuron precursors (MNR+ cell) occupy the ventral midline in Disp1{Delta}2/C829F (I) and Disp1{Delta}2/C829F, Shh+/– mutants (M), instead of its normal lateral position in wild type (A). V2 (Chox10+) and V1 (En1+) interneurons are present in comparable numbers in Disp1 mutants as the wild type (B,F,J,N). V0 (Evx1/2+) precursors expand ventrally in Disp1 mutants (C,G,K,O). Lim1/2-positive cells, which demarcate the p5, V0 and V1 precursor populations also expand ventrally in Disp1 mutants (D,H,L,P).





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