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Fig. 6. Cephalic mesoderm patterning is affected in Disp1{Delta}2/C829F mutants. (A-B) Alcian Blue- and Alizarin Red-stained skull from E18.5 dpc embryos. (C) Model of skeletal elements of the vertebrate skull. Elements formed by neural crest are labeled green and those by mesoderm are labeled purple. (D) Skull elements altered in Disp1{Delta}2/C829F mutants are highlighted in red, which overlap with most of the skeletal elements with mesoderm origin. (E,F) Ventral view of the base of the brain; note that the basioccipital bone (bo) and basisphenoid bones (bs) are misshapen and greatly reduced in Disp1{Delta}2/C829F mutant. Whole-mount in-situ hybridization of paraxial mesoderm markers FoxD1 (G,H), FoxD2 (I,J) show clear reduction in the cephalic mesoderm area in Disp1{Delta}2/C829F mutant.





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