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Fig. 2. A Phox2b enhancer that contains conserved Pbx-Hox and Prep/Meis sites. (A) The mouse Phox2b locus highlighting (red box) a 376 nucleotide (nt) proximal enhancer (P2b_0.38). (B) Sequence alignment between mouse, rat, human, zebrafish and fugu, showing high conservation. PH and P/M binding elements are boxed in red and green, respectively. (C) Comparison between PH and P/M sequences in Phox2b, Hoxb1 (ARE repeat 2) (Popperl et al., 1995) and Hoxb2 (Maconochie et al., 1997) r4 enhancers. The Phox2b and Hoxb1 PH and P/M core sequences are identical.





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