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Fig. 5. The PH site contributes to mouse Phox2b regulation in ventral r4 progenitors. (A,B) Dorsal views of whole-mount E10.5 mouse embryos carrying (A) P2b_10/lacZ or (B) P2b_10{Delta}PH/lacZ, containing an 11 bp deletion of the PH site (same as in Fig. 4B). No overt differences are apparent between mutated and wild-type constructs. (C,D) Cross-sections through ventral r4 of transgenic embryos carrying P2b_10/lacZ (C) or P2b_10{Delta}PH/lacZ (D). (D) Reporter expression is severely reduced in the ventricular zone (VZ) (delimited by the broken line) of the pMNv domain but not in the mantle layer (ML). lacZ expression is detected by in situ hybridization. The summary represents the expression pattern differences at E10.5 in ventral r4 of wild type P2b_10/lacZ and mutant P2b_10{Delta}PH/lacZ transgenic embryos. Red circles, strong expression; pink circle, weak residual expression. FP, floorplate.





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