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Fig. 7. Early female-specific markers are expressed in Pod1 KO XX gonads.
Whole-mount in situ hybridization for Wnt4 (A) and
follistatin (B) is shown in XY and XX gonads from 12.5 dpc embryos.
Expression of Dmc1, a marker of meiotic germ cells (C), is shown in
14.5 dpc embryos. Wnt4 is expressed in control XX gonads and
mesonephroi, and was increased in mesonephroi of XX mutants (–/–).
Follistatin is also expressed in XX mutant gonads, although the
expression is somewhat decreased as compared with controls. Dmc1
expression is similar in XX mutants and controls.
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