QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online August 18, 2004

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

microRNA holds back the boundary

Organ development in plant meristems requires that boundary domains around the primordia remain stable despite continuous growth and cell division. In Arabidopsis, the establishment and maintenance of the boundary around organ primordia of shoot apical and floral meristems is regulated by three partially redundant transcription factors, CUC1-CUC3. On p. 4311, Laufs et al. examine the interaction between these three transcription factors and a microRNA - miR164 - during boundary regulation. They show that miR164 targets cuc1 and cuc2, but not cuc3, mRNA for degradation, explaining why miR164 overexpression results in similar patterning and floral defects as cuc1 cuc2 double mutants. They also modified cuc2 mRNA to make it resistant to miR164-guided cleavage and found that this expanded the boundary domain. The authors propose that miR164 constrains the expanding boundary by clearing boundary cells of CUC1 and CUC2, thus changing their cell identity.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

MicroRNA regulation of the CUC genes is required for boundary size control in Arabidopsis meristems

Patrick Laufs, Alexis Peaucelle, Halima Morin, and Jan Traas
Development 2004 131: 4311-4322. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?