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Fig. 2. Utricle formation in Hr-/- mice. (A) Histology of
backskin from Hr-/- mice. Hematoxylin-Eosin staining of
sagittal sections from backskin at the indicated ages and genotypes.
Arrowheads indicate morphological change in the infundibulum of
Hr-/- skin. (B) Expression of keratin markers in utricles.
Immunohistochemical detection of keratin markers in consecutive serial
sections of backskin from P19 Hr-/- (top panels; -/-) and
wild-type (+/+) mice (bottom panels). H&E, Hematoxylin-Eosin; K10, keratin
10; K14, keratin 14; K17, keratin 17. Arrowheads indicate positive signal in
utricle; arrows indicate epithelial remnants; thick arrows indicate sebaceous
glands. (C) Utricles (arrowheads) do not express hair markers.
Immunohistochemical detection of Trichohyalin, a hair marker, in P15
Hr-/- backskin. (D) Immunofluorescent detection of K10
(red) and K17 (green) in sagittal skin sections from P19
Hr-/- and wild-type mice. Brackets indicate expansion of
K10-positive region. Scale bars: 50 µm.
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