Supplemental Figure 1
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Fig. S1.
Expression of FGFs and FGFRs in the chicken inner ear. The inner ears of
whole-mount embryos hybridized with an Fgf10 cRNA probe at E2.5
(A) and E4 (B) are shown. (A) The arrowhead indicates the neurogenic region.
(B) The black arrow indicates the anterior crista, the red arrow points to the
posterior crista, and the asterisk marks a large Fgf10 expression domain that includes the lateral crista
and macula utriculi. Adjacent sections through the posterior crista at E3.5-E4
hybridized with either Fgf10 (C)
or Bmp4 probes (D). (E) Inner ear
of a whole-mount embryo hybridized with an Fgf3 probe at E4; the asterisk and black arrow indicate
the same sensory patches as in B. Gene expression patterns of (F) Fgfr1 and (G) Fgfr2 in the canal pouch at E5. Both genes are expressed strongly in the
endolymphatic duct and surrounding mesenchyme, and weakly in the epithelia of
the canal pouch (arrowheads). PC, posterior crista; ed, endolymphatic duct/sac;
A, anterior; D, dorsal; P, posterior; M, medial, L, lateral.
