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Fig. 4. Ectopic FGF treatments. Paint-filled inner ears were harvested on E7 (A,B)
or E9 (C-J). Embryos were injected with viruses (A-F) or implanted with beads
(G-J), as indicated in each panel. Viruses were delivered to the otocyst lumen
on E2.5-3, except for the ear shown in E, which received injections into the
periotic mesenchyme on E4. Beads were implanted on E4 (G,J) or E5 (H,I). White
arrows denote defective regions and arrowheads are described in detail in the
text. Black arrowheads in D and F indicate normal locations of the canal
pouches. For illustration of the common crus phenotype, the endolymphatic duct
was removed from the inner ears shown in E, H and I. Abbreviations are as in
Fig. 1. AA, anterior ampulla;
LA, lateral ampulla; PA, posterior ampulla. Orientations in C apply to all
panels. Scale bars: in B, 100 µm for A,B; in G, 200 µm for C-J.
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