spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 8. Schematic drawing to show the organizing activity of Fgf8 and its signal transduction. Fgf8 is induced at the interface of Otx2 and Gbx2 expression, overlapping with Gbx2 expression. The site where Fgf8 mRNA is localized may receive a strong Fgf8 signal and cause the Ras-ERK pathway to be activated. Thus, this region may acquire the characteristics of rhombomere1 (r1), where cerebellum differentiates. By contrast, in the mesencephalon, the Fgf8-Ras-ERK pathway may be activated only weakly, which may play a role in rostrocaudal polarity formation of the tectum.





Right arrow Return to article