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Fig. 2. Rb ablation results in epithelial abnormalities. (A-L) Morphological
examination, TUNEL analysis and immunohistochemisty for Ki67 and PCNA in lungs
from day 1 pups after Rb ablation (CC10-rtTA), from genetically identical pups
without doxycycline treatment (No Dox), and from pups lacking one or both
transgenes (Control). Arrows mark apoptotic cells (A), TUNEL-positive cells
(D,E) and scattered PCNA-positive cells (K,L). Abbreviations are as in
Fig. 1. (M) Quantification of
epithelial apoptosis and proliferation as assessed by the percentage of
TUNEL-positive and Ki67-positive cells, respectively. Rb ablation results in
statistically significant increases in epithelial apoptosis and proliferation
(*P<0.0002). Data represents the analysis of seven
CC10-rtTA, eight control and four No Dox mice.
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