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Fig. 7. Rb family deficiency results in cell lineage-specific effects in
differentiation. (A-F) Immunohistochemical analysis for CCSP and CGRP in
transgenic and wild-type (WT) control lungs. Arrows mark neuroendocrine cells.
Data is representative of three to six CC10-T121 founder mice and two SPC-T121
pups. (G) Immunohistochemistry for the transgene (T121) and CCSP in a
CC10-T121 founder with a less severe phenotype. Note that transgene expression
(green) and CCSP expression (red) do not overlap. Abbreviations are as in
Fig. 1. (H) Quantification of
CGRP-immunoreactive foci. CC10-T121 mice show increased CGRP-reactive foci
when compared with wild-type (WT) (*P=0.0002) and SPC-T121
(*P=0.0008) mice. Data represent six CC10-T121 founder
mice, four wild-type mice and two SPC-T121 mice.
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