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First published online September 1, 2004

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Facing the complexities of jaw development

During craniofacial development, the lower jaw skeleton is derived from cephalic neural crest cells that are present in the mandibular region of the first pharyngeal arch. To investigate how mandibular identity is specified, Ruest et al. analysed mandibular development in endothelin-A receptor (Ednra) null mouse embryos, which are born with severe craniofacial defects (see p. 4413). The researchers report that most of the lower jaw structures in Ednra^–/– embryos are homeotically transformed into upper jaw structures, which are similar changes to those seen in mice lacking two downstream effectors of Ednra signalling – the distal-less homeobox genes Dlx5 and Dlx6. These structural changes are preceded by disrupted gene expression in the mandibular arch, except for in one region possibly involved in lower incisor development. Thus, suggest the researchers, establishing mandibular identity requires both Ednra-dependent and -independent signalling pathways.

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Related articles in Development:

Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity

Louis-Bruno Ruest, Xilin Xiang, Kim-Chew Lim, Giovanni Levi, and David E. Clouthier
Development 2004 131: 4413-4423. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?