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First published online September 1, 2004

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New retina anyone?

Untreated retinal detachment inevitably causes blindness in humans. However, birds, fish and urodele amphibians are luckier – they can regenerate their retinas. On p. 4607, Spence and co-workers investigate this process in chick embryos. They describe how two modes of retinal regeneration – transdifferentiation of retina pigmented epithelium (RPE) and activation of stem/progenitor cells in the ciliary body and ciliary marginal zone (CB/CMZ) – are both stimulated by Fibroblast growth factor 2 (Fgf2). In addition, they show that ectopic expression of Sonic hedgehog (Shh) stimulates regeneration from the CB/CMZ in the absence of Fgf2, and that Shh-induced regeneration requires Fgf signalling. By contrast, ectopic Shh expression inhibits retinal regeneration via RPE transdifferentiation, indicating that Shh is involved in RPE maintenance. Spence et al. conclude that the hedgehog pathway is an important modulator of both types of retinal regeneration.

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Related articles in Development:

The hedgehog pathway is a modulator of retina regeneration

Jason R. Spence, Mayur Madhavan, John D. Ewing, David K. Jones, Bret M. Lehman, and Katia Del Rio-Tsonis
Development 2004 131: 4607-4621. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?