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First published online September 1, 2004

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HOXA13 and BMPs link limbs

Although many of the genes involved in limb development have been identified, little is known about their transcriptional regulation. On p. 4581, Knosp and co-workers report that HOXA13, a transcription factor whose absence causes developmental defects in mammalian digits and interdigital tissue, controls distal limb morphogenesis by directly regulating the expression of bone morphogenetic proteins (BMPs) 2 and 7. The researchers show first that Bmp2, Bmp7 and Hoxa13 are co-expressed during normal mouse limb development, and that absence of functional HOXA13 reduces Bmp2 and Bmp7 expression in the affected limb tissues. Then, they identify and characterise enhancer regions in Bmp2 and Bmp7 that interact with the HOXA13 DNA-binding domain in vitro and in vivo. Finally, they show that exogenously applied BMP2 or BMP7 partly rescues the Hoxa13 mutant limb phenotype. These results thus identify an important mechanistic link between two well-characterised families of developmental factors.

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HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis

Wendy M. Knosp, Virginia Scott, Hans Peter Bächinger, and H. Scott Stadler
Development 2004 131: 4581-4592. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?