QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online September 1, 2004

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Gasping for air

Early embryos get the oxygen they need for metabolism by diffusion. After gastrulation, however, efficient oxygen delivery requires a cardiovascular system. On p. 4623, Ramírez-Bergeron and colleagues use a mouse embryonic stem (ES) cell culture system to show that hypoxic responses are important for establishing the early mesoderm and its differentiation into haemangioblasts – bipotential precursors of endothelial and haematopoietic cells. They report that hypoxia accelerates the expression of Brachyury (a mesoderm-patterning gene), BMP4 (a mesoderm-promoting growth factor) and FLK1 (the receptor for vascular endothelial growth factor and a marker for haemangioblasts). This response depends on hypoxia inducible factor (HIF), as ES cells null for the HIF subunit aryl hydrocarbon receptor nuclear translocator (ARNT) produce fewer FLK1⁺ cells in normoxic and hypoxic conditions. The researchers conclude that ineffective responses to hypoxia underlie the previously observed failure of Arnt^–/– embryos to form a functional cardiovascular system.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Hypoxia affects mesoderm and enhances hemangioblast specification during early development

Diana L. Ramírez-Bergeron, Anja Runge, Karen D. Cowden Dahl, Hans Joerg Fehling, Gordon Keller, and M. Celeste Simon
Development 2004 131: 4623-4634. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?