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Fig. 4. Gata3 in mandibular arch development. E10.5 wild-type
(Gata3+/+, A,C,E,G; Ednra+/+, I,K),
Gata3–/– (B,D,F,H) and
Ednra–/– (J,L) embryos following whole-mount
in situ hybridization analysis using DIG-labeled riboprobes against
Hand2 (A-D), Dlx5 (E-H) and Gata3 (I-L). Embryos
are shown in both lateral (A,B,E,F,I,J) and ventral (C,D,G,H,K,L) views. (A-D)
Unlike wild-type embryos (A,C), Hand2 expression in
Gata3–/– embryos is observed only in the
rostral mandibular arch (B,D); expression is also decreased in the second
arch. There is an overall decrease in arch size in
Gata3–/– embryos. (E-H) Dlx5
expression is observed only along the rostral half of the mandibular arch of
Gata3–/– embryos (F,H). (I-L) Mandibular arch
expression of Gata3, observed in the distal arch mesenchyme of
wild-type embryos (I,K), appears unchanged in
Ednra–/– embryos (J,L). 1, mandibular region
of the first pharyngeal arch; 2, second pharyngeal arch; h, heart; lb, limb
bud; np, nasal prominence.
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