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Fig. 6. Sox4 is downregulated in Foxp1 null hearts. In-situ
hybridization for Sox4 (A-E), Foxc1 (H,I) and Foxc2
(J,K) and immunohistochemistry for fibronectin (F,G) was performed on
wild-type (A,D,F,H,J) and Foxp1–/–
(B,C,E,G,I,K) E11.5 (A-C) and E14.5 (D-K) embryo sections. Sox4 gene
expression is significantly decreased in the outflow tract region of
Foxp1–/– hearts at both E11.5 and E14.5 (A-C),
while Foxc1, Foxc2 and fibronectin expression is unchanged. Scale
bars: 800 µm in D,E,H-K; 400 µm in A-C,F,G.
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