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Fig. 9. Wun2 activity in pole cells competes with somatic Wun and Wun2 activities
for pole cell survival. Embryos were stained for Vasa to visualize pole cells.
(A) A wun2m– embryo showing the drastic pole cell
loss phenotype. (B) An embryo lacking both maternal Wun2 and zygotic Wun and
Wun2 showing partial suppression of the pole cell death phenotype of
wun2m– embryos. (C) Overexpression of wun2
in the mesoderm leads to pole cell death. (D) An embryo overexpressing
wun2 both in pole cells and the mesoderm shows a partially suppressed
pole cell death phenotype caused by the overexpression of wun2 in the
mesoderm alone (C).
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