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Fig. 7. Cell death and proliferation in Bmp7cre/+;Smad4–/CA kidneys. Sections of wild-type (WT; A,C,E) and Bmp7cre/+;Smad4–/CA (Mut; B,D,F) kidneys were examined at E12.5 (A,B), E14.5 (C,D) and E16.5 (E,F) for pyknotic nuclei (marked by arrowheads) as markers of cell death. Wild-type kidneys display only sporadic single dead cells adjacent to nephrogenic mesenchyme. By contrast, mutant kidneys show clusters of cell death within the thickened peripheral cell layer, mainly concentrated to regions distant from collecting duct tips. PCNA immunohistochemistry was used to identify proliferating cells in wild-type (G,I) and mutant (H,J) kidneys at E12.5 (G,H) and E14.5 (I,J). Both wild type and mutant proliferating cells are similarly distributed in collecting ducts and mesenchyme.





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