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Fig. 9. Cellular effects of Shh manipulations. (A) KAAD/Fgf2-treated eyes show a significantly increased number of Brn3a-positive ganglion cells compared with Fgf2-treated eyes (P<0.001). This corresponds to a 23.09% increase in the number of ganglion cells. Rcas-Shh/Fgf2-treated eyes have a significantly lower number of ganglion cells (P<0.001) than Fgf2-treated controls, corresponding to a 42.98% decrease in the number of ganglion cells. (B) Rcas-Shh/Fgf2-treated eyes show increased cell death throughout the retina when compared with Fgf2 (P<0.001) and KAAD/Fgf2-treated eyes. There is no significant difference between KAAD/Fgf2 eyes and Fgf2-treated eyes. (C) Rcas-Shh/Fgf2-treated eyes also show increased cell death in the presumptive ganglion cell layer, compared with Fgf2-treated controls P<0.001). There is no statistically significant difference in cell death between KAAD/Fgf2-treated eyes and Fgf2-treated eyes. * denotes statistical significance. Error bars shown are s.e.m.





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