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Fig. 6. The BL-CFC defect in Arnt–/– cells is cell extrinsic. (A) Arnt+/+ neos lacZ– and Arnt–/– neor lacZ+ ES cells co-cultured during EB differentiation, dissociated and replated in methylcellulose with or without G418. (B) Under G418 selection, all surviving BL-CFCs stained blue indicating ß-galactosidase activity from Arnt–/– neor lacZ+ cells. Wild-type clones only survived in the absence of G418.





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