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Fig. 7. Model of ARNT activity during early embryonic development. HIF responses are required for the proper differentiation, survival or proliferation of mesoderm and hemangioblasts. In the absence of ARNT, mesoderm differentiation is delayed. Furthermore, ARNT deficiency results in reduced mesoderm differentiation and increased transitional cell numbers, suggesting a block in commitment to the hemangioblast phenotype. Fewer hemangioblasts lead to a reduction in the numbers of hematopoietic and endothelial precursors.





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