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Fig. 7. Model for neural crest lineage segregation. Neural crest (NC) progenitors
identified by in vitro clonal analysis are ordered according to their number
of developmental potentials [data taken from elsewhere
(Baroffio et al., 1991;
Trentin et al., 2004)]. In
the cephalic NC, neurons (N), glia (G), melanocytes (M) and mesectodermal
derivatives – myofibroblasts (F) and cartilage (C) – arise from
diverse `intermediate' pluripotent and bipotent progenitors, which suggest
that committed cells are generated through progressive restrictions in the
potentialities of a putative `totipotent-like' NC stem cell (broken circle).
In the trunk NC, clonogenic cells endowed with chondrogenic potential (blue)
are not recovered; however, various myofibroblastic (non-chondrogenic)
progenitors (pink) are present as in the cephalic NC. Self-renewal was
demonstrated for rat trunk GNF-like cells
(Stemple and Anderson, 1992),
and for quail trunk and cephalic GM and GF progenitors
(Trentin et al., 2004).
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