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Fig. 8. Expression of FGFs in the SMP at E10.5. (A,B) Both Fgf9 and
Fgf10 are expressed in the SMP and underlying mesenchyme.
Fgf10 is expressed in the ventral domain of the SMP and to a lesser
extent in the mesenchyme between the dorsal pancreas and the SMP (A).
Fgf9 (B), and its high affinity receptor Fgfr3 (C), are
expressed in the dorsal region of the SMP and towards the tip of this
structure as it develops in a leftward direction. In the
Bapx1/ mutant (D), Fgf10 is
downregulated in the ventral SMP, but is still detectable in the underlying
mesenchyme.