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Fig. 9. Model for asymmetry in the spleno-pancreatic region. The model describes
the major events that occur in lateral organ morphogenesis. The left SMP is
under the influence of the LR genetic cascade and is maintained whereas the
right SMP is lost. Cell proliferation in the SMP appears to be the motive
force in the lateral growth that occurs in the SMP between E9.5 and E10.5 of
development. During this period, the population of mesenchymal cells
underlying the SMP expands considerably and the dorsal region is induced
(perhaps by the associated SMP) to become spleen. Outgrowth of the
spleno-pancreatic region is compromised by loss of Bapx1, as is
Fgf10 expression in the ventral SMP. The high expression of
Fgf10 from the SMP may be the chemotactic factor to which the dorsal
pancreas responds.
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