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Fig. 1. Frodo and Dapper are required for head development. Two blastomeres of four-cell stage embryos were injected in the dorsal equatorial region with morpholinos and mRNAs as indicated in Table 1. (A) Control morpholino (CoMO)-injected embryos. (B,C) Embryos injected with FrdMO or DprMO show shortened axes with head defects. (D) Co-injection of FrdMO and DprMO leads to severe head defects. (E) The effects of FrdMO and DprMO are reversed by Frodo RNA lacking the target sequences. (F) Head development is rescued in FrdMO and DprMO-injected embryos by stabilized ß-catenin (ßcat) RNA. Shortened axes are rescued by Frodo RNA, but not by ßcat RNA.





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