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Fig. 5. Fgf10 signaling regulates Sp8 and Sp9. Dorsal views of
Sp8 expression (A,B) and Sp9 expression (C,D) in E9.5 mouse
embryos. (E-H) Dorsal views of Sp8 expression in chick limb buds.
(I-L) Dorsal views (I,J) and ventral views (K,L) of Sp9 expression in
chick limb buds. All panels are with the anterior towards the top. (A-D)
Sp8 and Sp9 expression detected in wild-type mouse embryos
(A,C, black arrowheads), was significantly downregulated in
Fgf10–/– embryos (B,D, red arrowheads).
Implantation of Fgf10-soaked beads upregulated chick Sp8 expression
in the surface ectoderm and in the AER after 6 hours (F; compare with the
contralateral control, E). Implantation of SU5402-beads downregulated
expression of chick Sp8 in the AER after 24 hours (red arrowhead in
H; compare with the contralateral control, G). Implantation of Fgf10-beads
upregulated chick Sp9 expression in the surface ectoderm and in the
AER after 6 hours (J; compare with the contralateral control, I). Implantation
of SU5402-beads downregulated expression of chick Sp9 in the AER
after 24 hours (red arrowhead in L; compare with the contralateral control,
K). Arrowheads in E,F and I,J indicate the anterior margin of the expression
domain. The asterisks in F,H,J,L indicate implanted beads.
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