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Fig. 6. The expression of a dominant-negative variant of Gata2 results in
a reduction of Th, Scg10, Dbh and Phox2b expression. Chick
embryos were infected unilaterally at E2 with either RCAS-dnGata2 or
RCAS-engrailed and RCAS-VP16-Gata2 as controls and analysed at E8 for the
expression of Th (A), Scg10 (B), Dbh (C) and
Phox2b (D) in infected sympathetic ganglia. The areas of
Th-, Scg10-, Dbh- or Phox2b-expressing
cells were quantified on alternate sections, both on the infected and the
contralateral uninfected side. For the RCAS-engrailed and RCAS-VP16-Gata2
controls, only data of the infected ganglia are shown for simplicity; the data
of the uninfected side are identical. The data represent the
mean±s.e.m. of at least nine embryos. (A) * significantly
different from engrailed-infected side, VP16-Gata2-infected side and
dnGata2-uninfected side (P<0.001, P<0.005,
P<0.005, respectively). (B) * significantly different
from engrailed-infected side, VP16-Gata2-infected side and
dnGata2-uninfected side (P<0,005, P<0,01,
P<0.01, respectively). (C) * significantly different
from dnGata2-uninfected side (P<0.005). (D) *
significantly different from dnGata2-uninfected side (P<0.01) (all
Student's t-tests).
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