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Fig. 9. Gata2 expression in peripheral nerve precursors results in the
generation of neurons that display mostly a non-autonomic phenotype. Chick
embryos were infected by RCAS-Gata2 at E2 and analysed at E8 for the
expression of ectopic neurons in the brachial nerve. Whereas a large number of
Scg10-positive cells was detected (A, overview; B, enlargement of the
region of the nerve), only few cells expressing autonomic marker genes (C,
Phox2b; E, Cash1) or noradrenergic markers (D, Th)
were present. This is confirmed by double in-situ hybridisations for
Scg10 (red, F) and Th (blue, G). Please note the low number
of cells that coexpress Scg10 and Th (arrow) and of
Th+, Scg10– cells (arrowheads).
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