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Fig. 4. Cubn is not properly localized to the apical cell surface of the VE in amn. Immunohistochemical analyses of serial paraffin sections of an E7.5 wild-type embryo (A-C) and an E7.5 amn mutant (D-F), which were counterstained with Hematoxylin. The regions designated by brackets in A-F are shown at high magnification in a-f. (A,a) Megalin, (B,b) Amn and (C,c) Cubn co-localize to the apical cell surface (red asterisks) of the VE in the wild-type embryos. The basal cell surface faces the epiblast (red arrowheads). (D,d) Megalin staining of the apical cell surface of the VE in amn, identified by the absence of Amn antibody staining in the adjacent section (E,e). (F,f) Cubn appears cytoplasmic and not apical in amn. (a and d, inset) Lysozyme staining in wild-type (a) and amn mutant (d) embryos.





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