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Fig. 2. GLD-1-dependent repression of GLP-1/Notch results in underproliferation of
germ cells in ATX-2-depleted gonads. (A) The mean number of
phosphorylated-H3-positive, mitotic nuclei per gonad arm (n=number of
gonad arms)±mean deviation, was determined for animals with the
indicated genotypes. The fem-3(gf) and fem-1 mutations
masculinize and feminize the germline, respectively. Depletion of GLD-1
restored the number of mitoses in gld-1;atx-2(RNAi) gonads to the
wild-type level. (B-G) Magnified images of the distal gonad after staining for
GLP-1 (B-D) or GLD-1 (E-G). Abnormally high levels of GLD-1 are present in the
distalmost part of masculinized atx-2(RNAi) gonads (F), but not in
many feminized, fem-1;atx-2(RNAi) gonads as shown here (G). Scale
bars: 50 µm.
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