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Fig. 3. Pcm mutant mice show a semidominant defect in spleen development during late embryogenesis. (A) Spleen development and size appear consistent across all genotypes at E15.5. Original magnification 40x. (B) By E17.5, significant reduction in spleen size is observed in Pcm mutants, more severe in homozygotes. Compare with A and note that spleen size in homozygotes regresses. Original magnification 40x. At P0 (C) and 7 weeks (D), spleens (arrowheads) of homozygous mutants maintain consistent decrease in size, whereas heterozygotes undergo a significant increase in size from P0 to 7 weeks. Original magnification (C) 16x and (D) 6x. H&E staining of spleen sections at P0 (E) and 7 weeks (F) reveals red and white pulp compartmentalization of wild-type and mutant spleens; arrowhead indicates white pulp follicle. Original magnification (E) 200x and (F) 50x.





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