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Fig. 6. Intact white pulp follicles but aberrant red pulp sinusoidal architecture in Pcm mutant spleens. Immunohistochemistry of hematopoietic lineage markers Ter119 (A), B220 (B), and CD3 (C) within the spleen at 12 weeks of age. Arrowheads denote central arteriole. (D) MAdCAM-1 immunohistochemistry indicates the presence of marginal sinuses in Pcm mutant spleens at 12 weeks of age. Immunohistochemistry of IBL-7/1 (E), IBL-9/2 (F), and IBL-7/22 (G) demonstrates abnormal arrangement of the microvasculature endothelial components of the red pulp in Pcm mutant spleens at 12 weeks of age. Original magnification, 200x.





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