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Fig. 8. Genetic models of mouse female infertility because of blockage of early embryonic development. The left column specifies the stage of development along the oviduct. The right column lists the genes associated with blockage at each stage. The zona pelucida protein Zp3 has been implicated in impaired fertilization (Liu et al., 1996; Rankin et al., 1996). Disruption of Npm2 (Burns et al., 2003), Zar1 (Wu et al., 2003) and Hsf1 (Christians et al., 2000) impedes the first cleavage step. Blockage at the two-cell stage is observed with disruption of Zfp36l2 ({Delta}N-Zfp36l2) and MATER (Tong et al., 2000).





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